September 2008

Volume 25, Issue 3

Cariogenic and erosive potential of the medication used by HIV-infected children: pH and sugar concentration

Authors: L. Pomarico G. Czauski M.B. Portela I.P.R. de Souza L. Kneipp R.M. de Araújo Soares G.F.B de Araújo Castro
doi: 10.1922/CDH_2170Pomarico03

Abstract

Objective The aim of this work was to analyze pH and sugar concentration in seven antiretroviral and three antibacterial medications frequently prescribed to HIV infected paediatric patients. Method Sugars (sucrose, glucose, lactose and fructose) and pH were measured from every one of ten medications with different serial numbers in two samples. The pH was determined by a previously calibrated digital pHmeter (Beckman™). Analysis of free sugars was performed using thin-layer chromatography (TLC). The pH results and the amount of sugar originated from the two samples in each lot were added. The arithmetic mean of these results were computed. Results Two antiretrovirals (Zidovudin and Abacavir Sulphate) had pH below critical level (3.55 and 3.93, respectively). All three antibacterials analyzed had pH above 5.5, and one of them (Azithromycin) had the highest pH level of the ten medications examined (9.28). Sugar was present in seven out of 10 of the medications analyzed. The antibacterials contained the highest concentration of sucrose, ranging from 40% to 54%. Glucose was found in one of the ten, sucrose was present in seven of them and none showed lactose. Fructose was not observed with the technique used. Conclusions A number of medications frequently used by HIV-infected children may cause a significant risk of both caries and dental erosion. Key words: Child, HIV, medicines, oral health, sugars.

£10 single article

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Association between breastfeeding duration and non-nutritive sucking habits 161-165 £10 single article
I want braces: factors motivating patients and their parents to seek orthodontic treatment. 166-169 £10 single article
Cariogenic and erosive potential of the medication used by HIV-infected children: pH and sugar concentration 170-172 £10 single article
Prevalence of breath malodour in 7-11 year old children living in Middle Anatolia, Turkey. 173-177 £10 single article
Enamel fluorosis in 12- and 15-year-old school children in Costa Rica. Results of a National Survey, 1999 178-184 £10 single article
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Short Communication - Fissure sealants on permanent first molars – consequences of a one-year delay 191-192 £10 single article

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