March 2022

Volume 39, Issue 1

The impact of HPV vaccination on the prevention of oropharyngeal cancer: A scoping review

Authors: Katherine H. Kaczmarczyk Huda Yusuf
doi: 10.1922/CDH_00072Kaczmarczyk08


Introduction: HPV-associated oropharyngeal cancer (OPC) has one of the most rapidly rising incidences of any cancer in high-income countries. HPV vaccination is being tested to prevent HPV-associated OPC. Objective: To determine the effect of Human Papilloma Virus (HPV) vaccination on the prevention of OPC in adults worldwide. Basic research design: Scoping review conducted using PRISMA-ScR Checklist. Method: An electronic literature search identified relevant records. Titles and abstracts were screened to assess eligibility by two researchers, and data from relevant full-text articles were extracted and synthesised. Results: Three-hundred-and-forty-three studies were identified, with eleven articles meeting the inclusion criteria. The most common study design was cross-sectional (n = 7), the most common location was the US (n = 6) and data collection periods spanned 2004 to 2020. One article found unvaccinated participants had a 19 times increased risk of developing OPC compared with those who had been vaccinated against HPV. The remaining papers showed that prevalence of HPV-vaccine-type oral infection was significantly lower in vaccinated participants than unvaccinated participants, with a reduction of oral HPV detection ranging from 72% to 93%. This reduction varied by sex. Conclusions: There is evidence to suggest that HPV vaccination reduces oral HPV infection and decreases the incidence of HPV-associated OPC. There is substantial need for further research which directly examines the relationship between HPV vaccination status and subsequent OPC development. Keywords: Prevention, review, vaccination, alphapapillomavirus, oropharyngeal neoplasms

£10 single article

Other articles in this issue

Article Pages Access
CDH Board 2022 1-1 Download
Acknowledgement of Reviewers 2-2 Download
Editorial: Going forward, not straight. 3-3 Download
Dental Public Health in Action: The covid-19 restrictions on dentistry in England and their impact on access to dental care for high-risk patient groups in the North-East and North Cumbria 4-7 Download
Sociodemographic and Clinical Factors That Influence Oral Health-Related Quality of Life in Adolescents: a Cohort Study 8-13 £10 single article
The impact of HPV vaccination on the prevention of oropharyngeal cancer: A scoping review 14-21 £10 single article
Effectiveness of The Wikipedia Collaboration of Dental Schools’ Training Programme: a new Paradigm for Teaching and Learning of Evidence-Based Dentistry 22-26 Download
Innovative methodology to guide planning of dental workforce distribution: a GIS-based study in Nepal 27-32 £10 single article
Diet drinks and dental caries among U.S. adults: cluster analysis 33-39 £10 single article
Effect of social isolation on oral health status - A systematic review 40-45 £10 single article
Links between oral health-related quality of life in US adults and type 2 diabetes: structural equation modeling analysis 46-53 £10 single article
Dental fluorosis among 15- year- old school children in an endemic district in Sri Lanka 54-58 £10 single article
Social justice, activism and dentistry in the era of #BLM 59-63 £10 single article
Letter to the Editor 64-64 £10 single article


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