March 2023

Volume 40, Issue 1

Is There An Association Between Periodontitis And Non-Alcoholic Fatty Liver Disease? A Systematic Review and Meta-Analysis

Authors: Feiyan Xu Jimei Tang
doi: 10.1922/CDH_00180Xu06


Background: Studies have reported varying relationships between periodontitis and non-alcoholic fatty liver disease (NAFLD). This review aimed to summarise evidence by pooling published data on the association between periodontitis and NAFLD. Methods: PubMed, CENTRAL, Web of Science, and Embase databases were searched for cross-sectional, case-control, or cohort studies published up to 20th June 2022. The PICO statement was: In the general Population does the presence of periodontitis (Intervention) as compared to no periodontitis (Comparison) lead to NAFLD (Outcome). All included studies were to report the association between periodontitis and NAFLD using odds ratios (OR) or risk ratios with 95% confidence intervals (CI). Random effects meta-analysis was conducted to obtain pooled OR with 95% CI. Results: Meta-analysis of seven studies with data of 192,815 participants found no association between periodontitis and NAFLD (OR: 1.04 95% CI: 0.97, 1.12). There was medium heterogeneity in the meta-analysis (I2=58%). The results did not change with the exclusion of any study. A small risk of NAFLD was noted in periodontitis patients on analysis of two cohort studies. Results were non-significant for other study types. Subgroup analysis based on the study population and diagnostic method for NAFLD also failed to find relationships. Conclusion: Current evidence fails to demonstrate a link between periodontitis and NAFLD. Keywords: Periodontitis, systemic diseases, fatty liver, oral


Other articles in this issue

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CDH Board 2023 1-1 Download
Acknowledgement of Reviewers 2-2 Download
Dental Public Health in Action: Delivering a domestic violence and abuse screening and identification training programme in North Staffordshire-based dental practices 3-8 Download
Parents’ Perception of Fissure Sealant Therapy in 6-12 Year Old Children: Evaluating a theory-driven intervention 9-15 £10 single article
Reciprocity in the intercultural conference space to improve Aboriginal oral health: A qualitative study 16-22 £10 single article
Impact of Establishing Dental Access for Preventable Infectious Dental Diseases (PIDD) in Medical Settings: Case Study from Rural Wisconsin 23-29 £10 single article
Contextual and individual determinants of tooth loss in the Afro-descendant older adult populations of different countries: a scoping review 30-36 £10 single article
Illness perception amongst individuals with periodontal diseases 37-41 £10 single article
Hospitalisations due to pulp and periapical conditions in Australian children from 1998-99 to 2017-18 42-46 £10 single article
Is There An Association Between Periodontitis And Non-Alcoholic Fatty Liver Disease? A Systematic Review and Meta-Analysis 47-52 Download
Effectiveness of strategies to increase participation in school-based epidemiological surveys: a rapid review 53-59 £10 single article
Ethnicity, Social Support and Oral Health Among English Individuals 60-66 £10 single article


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