September 2022

Volume 39, Issue 3

An update on oral cavity cancer: epidemiological trends, prevention strategies and novel approaches in diagnosis and prognosis

Authors: Mark Gormley Emily Gray Charlotte Richards Alex Gormley Rebecca C. Richmond Emma E. Vincent Tom Dudding Andrew R. Ness Steven J. Thomas
doi: 10.1922/CDH_00032Gormley09

Abstract

In the UK, the incidence of oral cavity cancer continues to rise, with an increase of around 60% over the past 10 years. Many patients still present with advanced disease, often resulting in locoregional recurrence and poor outcomes, which has not changed significantly for over four decades. Changes in aetiology may also be emerging, given the decline of smoking in developed countries. Therefore, new methods to better target prevention, improve screening and detect recurrence are needed. High-throughput ‘omics’ technologies appear promising for future individual-level diagnosis and prognosis. However, given this is a relatively rare cancer with significant intra-tumour heterogeneity and variation in patient response, reliable biomarkers have been difficult to elucidate. From a public health perspective, implementing these novel technologies into current services would require substantial practical, financial and ethical considerations. This may be difficult to justify and implement at present, therefore focus remains on early detection using new patient-led follow-up strategies. This paper reviews the latest evidence on epidemiological trends in oral cavity cancer to help identify at risk groups, population-based approaches for prevention, in addition to potential cutting-edge approaches in the diagnosis and prognosis of this disease. Keywords: Epidemiology, Oral Cancer, Survival, Risk Factors, Squamous Cell Carcinoma, Mouth Neoplasms

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Other articles in this issue

Article Pages Access
CDH Board 2022 153-153 Download
Editorial: Management of the oral health of care home residents in general and those with dementia 154-155 Download
Editorial: Oral health inequalities and the COVID-19 pandemic: time for action 156-157 Download
The Role of Area Deprivation in Explaining Ethnic Inequalities in Adult Oral Health in England 158-164 £10 single article
Self-reported satisfaction with teeth and associated factors in 12-year-olds 165-168 £10 single article
Oral health status and absence from school among 12 year olds 169-174 £10 single article
Anticipatory guidance and children’s oral health: A scoping review 175-180 £10 single article
Impact of the Covid pandemic on health care equity in NHS General Dental Practice. 181-186 £10 single article
Dental Anxiety as a Risk Factor for Facebook Intrusion 187-190 £10 single article
Impact of socioeconomic inequalities on dental caries in deprived children: a multilevel analysis 191-196 £10 single article
An update on oral cavity cancer: epidemiological trends, prevention strategies and novel approaches in diagnosis and prognosis 197-205 Download
The role of the mothers’ sense of coherence in predicting dental caries risk in children 206-210 £10 single article
Psychosocial impact of malocclusion in the school performance. A Hierarchical Analysis. 211-216 £10 single article

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